Determine whether NPC should be considered
Use this tool to evaluate clinical patterns and help determine whether infantile-onset NPC should be considered in your differential diagnosis.
This tool is intended to support clinical awareness and is not intended for diagnosis. It should be used for children with neurological symptoms beginning before 6 years of age.
Which neurological findings have you observed?
Select all neurological findings currently present or previously observed in your patient.1
Which current or historical visceral findings have you observed?
Select all current or historical visceral findings observed in your patient.1,2
Is there a known family history of NPC IN A BIOLOGICAL RELATIVE?
Select the option that best describes your patient's family history.
RESULTS
Genetic testing for NPC MAY BE APPROPRIATE
Based on the signs and symptoms selected, it may be appropriate to order genetic testing for NPC.
NEXT STEPS
Order genetic testing at no cost
Beren will provide patients meeting certain eligibility criteria with sponsored whole genome sequencing and familial variant testing.
Refer to an NPC-experienced center
Referral to NPC-experienced centers supports diagnosis, ongoing management, and multidisciplinary care coordination.
*Isolated, or with neurological manifestations.
†Pulmonary infiltrates or respiratory failure in infancy.
This tool is intended to support clinical awareness and is not intended for diagnosis. It should be used for children with neurological symptoms beginning before 6 years of age.
Order genetic testing at no cost
Beren will provide patients meeting certain eligibility criteria with sponsored whole genome sequencing and familial variant testing.
Refer to an NPC-experienced center
Referral to NPC-experienced centers supports diagnosis, ongoing management, and multidisciplinary care coordination.
RESULTS
Additional clinical evaluation may be needed.
Based on the information provided, additional assessment is needed to determine the level of suspicion for NPC. Consider referral to an NPC-experienced center for further evaluation.
NEXT STEPS
Refer to an NPC-experienced center
Referral to NPC-experienced centers supports diagnosis, ongoing management, and multidisciplinary care coordination.
*Isolated, or with neurological manifestations.
†Pulmonary infiltrates or respiratory failure in infancy.
This tool is intended to support clinical awareness and is not intended for diagnosis.
It should be used for children with neurological symptoms beginning before 6 years of age.
Refer to an NPC-experienced center
Referral to NPC-experienced centers supports diagnosis, ongoing management, and multidisciplinary care coordination.
RESULTS
Genetic testing for NPC MAY BE APPROPRIATE
Based on the signs and symptoms selected, it may be appropriate to order genetic testing for NPC.
NEXT STEPS
Order genetic testing at no cost
Beren will provide patients meeting certain eligibility criteria with sponsored whole genome sequencing and familial variant testing.
Access genetic testing
Refer to an NPC-experienced center
Referral to NPC-experienced centers supports diagnosis, ongoing management, and multidisciplinary care coordination.
Find a specialist
*Isolated, or with neurological manifestations.
†Pulmonary infiltrates or respiratory failure in infancy.
This tool is intended to support clinical awareness and is not intended for diagnosis.
It should be used for child ren with neurological symptoms beginning before 6 years of age.
©2026 Beren Therapeutics P.B.C. All rights reserved. Beren and Mandos are trademarks of Beren Therapeutics P.B.C. DSA-1384-US-EN-v1 07/2026
RESULTS
Additional clinical evaluation may be needed.
Based on the information provided, additional assessment is needed to determine the level of suspicion for NPC. Consider referral to an NPC-experienced center for further evaluation.
NEXT STEPS
Refer to an NPC-experienced center
Referral to NPC-experienced centers supports diagnosis, ongoing management, and multidisciplinary care coordination.
Find a specialist
*Isolated, or with neurological manifestations.
†Pulmonary infiltrates or respiratory failure in infancy.
This tool is intended to support clinical awareness and is not intended for diagnosis.
It should be used for child ren with neurological symptoms beginning before 6 years of age.
©2026 Beren Therapeutics P.B.C. All rights reserved. Beren and Mandos are trademarks of Beren Therapeutics P.B.C. DSA-1384-US-EN-v1 07/2026
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